His male passenger was also taken to hospital with non-life-threatening injuries.
The other vehicle, believed to be a white Camry sedan, was seen speeding alongside the Ford ute between Wellington and Springvale roads and did not stop following the crash.
Detective Senior Sergeant Gerard Clanchy said officers are investigating whether the pair of vehicles were “driving in a reckless manner” before the crash.
“It appears that the driver of the Ford [ute] was travelling at excessive speed when he has lost control, rolled his vehicle and and collided with a concrete pillar of the overpass,” he said.
“I am appealing for the driver of the Camry sedan to come forward to police, so we can get a better understanding of the circumstances around this collision and any role he has played in the crash itself.
“We have some good avenues of inquiry involving dashcam footage that will lead us to identify that vehicle, but I suggest that driver come forward at the earliest opportunity.”
Major collision investigation unit detectives remained at the scene on Tuesday morning. The freeway was cordoned off while evidence was collected.
Inbound lanes on the Monash Freeway remained closed between Springvale Road and Ferntree Gully Road until about 10.30am on Tuesday morning.
Detectives are appealing for any witnesses or motorists with information or dashcam vision of the cars racing prior to the collision near the EastLink overpass to come forward.
Anyone with information is urged to call Crime Stoppers on 1800 333 000 or can submit a confidential report at www.crimestoppersvic.com.au
Catch all the day’s headlines
At the end of each day, we’ll send you the most important breaking news headlines, evening entertainment ideas and a long read to enjoy. Sign up here.
Ashleigh McMillan is a breaking news reporter at The Age. Got a story? Email me at email@example.com