The other vehicle, believed to be a white Camry sedan, was seen allegedly speeding alongside the Ford ute between Wellington and Springvale roads and the driver allegedly fled the scene following the crash.
Investigators have now arrested a 20-year-old Narre Warren South man who is assisting police with their inquiries.
No one has been charged in relation to the incident.
A vehicle has been located and seized as part of the investigation.
The 18-year-old passenger in the ute, also from Dandenong, was conveyed to hospital with non-life-threatening injuries.
Detective Senior Sergeant Gerard Clanchy said officers were investigating whether the vehicles were driving in a reckless manner before the crash.
“It appears that the driver of the Ford [ute] was travelling at excessive speed when he has lost control, rolled his vehicle and collided with a concrete pillar of the overpass,” he said.
Inbound lanes on the Monash Freeway remained closed between Springvale Road and Ferntree Gully Road until about 10.30am on Tuesday morning.
Detectives are appealing for any witnesses or motorists with information or dashcam vision of the cars racing prior to the collision near the EastLink overpass to come forward.